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A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications

Summary: 

SARS-CoV-2 epidemics raises a considerable issue of public health at the planetary scale. There is a pressing urgency to find treatments based upon currently available scientific knowledge. Therefore, we tentatively propose a hypothesis which hopefully might ultimately help save lives. Based on the current scientific literature and on new epidemiological data which reveal that current smoking status appears to be a protective factor against the infection by SARS-CoV-2 [1], we hypothesize that the nicotinic acetylcholine receptor (nAChR) plays a key role in the pathophysiology of Covid-19 infection and might represent a target for the prevention and control of Covid-19 infection.

Author: 
Jean-Pierre Changeux , Zahir Amoura,
place of publication: 
pubmed
Publication date: 
Tuesday, 9 June, 2020
Reference: 

Changeux JP, Amoura Z, Rey FA, Miyara M. A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications. C R Biol. 2020 Jun 5;343(1):33-39. doi: 10.5802/crbiol.8. PMID: 32720486.

Format: 
PDF
Library category: 
Strategies and tactics: 
Source: 
https://pubmed.ncbi.nlm.nih.gov/32720486/